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Lawrence A., J. T. Pronk, A. J. A. van Maris, R. M. Zelle, K. T. Madden, J. C. Harrison, J. Trueheart, C. Gancedo, C. Flores, and S. Bower. September 2010. Methods and microorganisms for production of C4-dicarboxylic acids. Patent WO/2010/111344.

http://www.wipo.int/patentscope/search/en/detail.jsf?docId=WO2010111344

Zelle R.M., J. Trueheart, J.C. Harrison, J.T. Pronk, and A.J.A. van Maris. 2010. Phosphoenolpyruvate carboxykinase as the sole anaplerotic enzyme in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 76:5383-5389. http://dx.doi.org/10.1128/AEM.01077-10

Zelle R.M., E. de Hulster, W. Kloezen, J.T. Pronk, and A.J.A. van Maris. 2010. Key process conditions for production of C4-dicarboxylic acids in bioreactor batch cultures of an engineered Saccharomyces cerevisiae strain. Appl. Environ. Microbiol. 76:744-750. http://dx.doi.org/10.1128/AEM.02396-09



Abbott D.A., R.M. Zelle, J.T. Pronk, and A.J.A. van Maris. 2009. Metabolic engineering of Saccharomyces cerevisiae for production of carboxylic acids: current status and challenges. FEMS Yeast Res. 9:1123-1136. http://dx.doi.org/10.1111/j.1567-1364.2009.00537.x



Zelle R.M., E. de Hulster, W.A. van Winden, P. de Waard, C. Dijkema, A.A. Winkler, J.A. Geertman, J.P. van Dijken, J.T. Pronk, and A.J.A. van Maris. 2008. Malic acid production by Saccharomyces cerevisiae: engineering of pyruvate carboxylation, oxaloacetate reduction, and malate export. Appl. Environ. Microbiol. 74:2766-2777. http://dx.doi.org/10.1128/AEM.02591-07