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Christopher F. Rose : Curriculum Vitae

Publications

Bosoi, C. R., Kumar, A., Oliveira, M. M., Welch, N., Clément, M.-A., Tremblay, M., Ten-Have, G. A. M., Engelen, M. P. K. J., Bémeur, C., Deutz, N. E. P., Dasarathy, S., & Rose, C. F. (2025). Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats. Metabolic Brain Disease, 40(1), 110. https://doi.org/10.1007/s11011-024-01525-2

Ouard, N., Tali, A., Souhoudji, T. D., Jebbouj, R., El-Bouchikhi, I., Rose, C. F., & Ahboucha, S. (2025). Different cortical and subcortical astroglial responsiveness in rats with acute liver failure. Journal of Neuropathology & Experimental Neurology, nlaf020. https://doi.org/10.1093/jnen/nlaf020

Sophasath, M., Tremblay, M., Hogue, C., Brisset, A., Tandon, P., Huard, G., Rose, C. F., & Bémeur, C. (2025). Evaluation of a nutritional education guide designed for patients living with cirrhosis: a randomized controlled mixed-methods study. Clinics and Research in Hepatology and Gastroenterology, 102672. https://doi.org/10.1016/j.clinre.2025.102672

Sophasath, M., Tremblay, M., Hogue, C., Dussault, A., Brassard, C., Vincent, C., Rose, C. F., & Bémeur, C. (2025). The use of technology platforms for nutrition education in cirrhosis: A cross-sectional study of patients’ acceptability and capabilities. Canadian Liver Journal, e20240058. https://doi.org/10.3138/canlivj-2024-0058

Trigui, A., Hogue, C., Tremblay, M., Huard, G., Rose, C. F., & Bémeur, C. (2025). Nutritional intake and diet quality over three years following liver transplantation. Clinical Nutrition ESPEN, 68, 669–678. https://doi.org/10.1016/j.clnesp.2025.06.026

Ballester, M. P., Rose, C. F., Carbonell-Asins, J.-A., & Jalan, R. (2023). Measuring and Interpreting Ammonia Levels in Cirrhosis. The American Journal of Gastroenterology, 118(7), 1297. https://doi.org/10.14309/ajg.0000000000002245

Cudalbu, C., & Cooper, A. J. L. (2023). Editorial for the special issue on Brain Biochemistry in Liver Disease. Analytical Biochemistry, 677, 115248. https://doi.org/10.1016/j.ab.2023.115248

L’Écuyer, S., Charbonney, E., Carrier, F. M., & Rose, C. F. (2023). Implication of Hypotension in the Pathogenesis of Cognitive Impairment and Brain Injury in Chronic Liver Disease. Neurochemical Research. https://doi.org/10.1007/s11064-022-03854-z

Pierzchala, K., Hadjihambi, A., Mosso, J., Jalan, R., Rose, C. F., & Cudalbu, C. (2023). Lessons on brain edema in HE: from cellular to animal models and clinical studies. Metabolic Brain Disease. https://doi.org/10.1007/s11011-023-01269-5

Ruiz, I., Rose, C. F., & Bémeur, C. (2023). Comment : Don’t put off till tomorrow what you can do today: Emphasis on pre-transplant management. JAMA Surgery, Online. https://doi.org/10.1001/jamasurg.2022.6387

Sophasath, M., Brisset, A., Rose, C. F., & Bémeur, C. (2023). Nutritional education strategies for patients with cirrhosis: A narrative review. Patient Education and Counseling, 115, 107878. https://doi.org/10.1016/j.pec.2023.107878

Tamnanloo, F., Ochoa-Sanchez, R., Oliveira, M. M., Lima, C., Lépine, M., Dubois, K., Bosoi, C., Tremblay, M., Sleno, L., & Rose, C. F. (2023). Multiple ammonia-induced episodes of hepatic encephalopathy provoke neuronal cell loss in bile-duct ligated rats. JHEP Reports, 100904. https://doi.org/10.1016/j.jhepr.2023.100904

Trigui, A., Rose, C. F., & Bémeur, C. (2023). Nutritional Strategies to Manage Malnutrition and Sarcopenia following Liver Transplantation: A Narrative Review. Nutrients, 15(4), 903. https://doi.org/10.3390/nu15040903

Jalan, R., & Rose, C. F. (2022). Heretical thoughts into Hepatic Encephalopathy. Journal of Hepatology, S0168827822001830. https://doi.org/10.1016/j.jhep.2022.03.014

Kroupina, K., Bémeur, C., & Rose, C. F. (2022). Amino acids, ammonia, and hepatic encephalopathy. Analytical Biochemistry, 649, 114696. https://doi.org/10.1016/j.ab.2022.114696

Macedo de Oliveira, M., Monnet-Aimard, A., Bosoi, C. R., Tremblay, M., & Rose, C. F. (2022). Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats. Journal of Neurochemistry, 162(4), 337–351. https://doi.org/10.1111/jnc.15661

Nguyen, M., Mukaneza, Y., Tremblay, M., Huard, G., Tang, A., Rose, C. F., & Bémeur, C. (2022). Renal dysfunction independently predicts muscle mass loss in patients following liver transplantation. Canadian Liver Journal. (world). https://doi.org/10.3138/canlivj-2021-0042

Raggi, C., Selleri, S., M’Callum, M.-A., & Paganelli, M. (2022). Generation of Complex Syngeneic Liver Organoids from Induced Pluripotent Stem Cells to Model Human Liver Pathophysiology. Current Protocols, 2(3), e389. https://doi.org/10.1002/cpz1.389

Clément, M.-A., Bosoi, C. R., Oliveira, M. M., Tremblay, M., Bémeur, C., & Rose, C. F. (2021). Bile-duct ligation renders the brain susceptible to hypotension-induced neuronal degeneration: Implications of ammonia. Journal of Neurochemistry, 157(3), 561–573. https://doi.org/10.1111/jnc.15290

DeMorrow, S., Cudalbu, C., Davies, N., Jayakumar, A. R., & Rose, C. F. (2021). 2021 ISHEN guidelines on animal models of hepatic encephalopathy. Liver International, 41(7), 1474–1488. https://doi.org/10.1111/liv.14911

For the US Acute Liver Failure Study Group, Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., & Rose, C. F. (2021). Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction. Digestive Diseases and Sciences, 66(1), 273–283. https://doi.org/10.1007/s10620-020-06166-w

Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., Rose, C. F., & For the US Acute Liver Failure Study Group. (2021). Elevated Serum Liver-Type Fatty Acid Binding Protein Levels in Non-acetaminophen Acute Liver Failure Patients with Organ Dysfunction. Digestive Diseases and Sciences, 66(1), 273–283. https://doi.org/10.1007/s10620-020-06166-w

Ochoa‐Sanchez, R., Oliveira, M. M., Tremblay, M., Petrazzo, G., Pant, A., Bosoi, C. R., Perreault, M., Querbes, W., Kurtz, C. B., & Rose, C. F. (2021). Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile-duct ligated rats. Liver International, 41(5), 1020–1032. https://doi.org/10.1111/liv.14815

Ochoa-Sanchez, R., Tamnanloo, F., & Rose, C. F. (2021). Hepatic Encephalopathy: From Metabolic to Neurodegenerative. Neurochemical Research, 46(10), 2612–2625. https://doi.org/10.1007/s11064-021-03372-4

Rose, C. F., & Jalan, R. (2021). Judging the value of ammonia measurement on lactulose dosing: Apples and oranges? Canadian Liver Journal, 4(1), 72–74. (world). https://doi.org/10.3138/canlivj-2020-0036

Rose, C. F., Jalan, R., & Shawcross, D. L. (2021). Erroneous Ammonia Measurement is Not Synonymous With a Lack of Efficacy of Ammonia-Lowering Therapies in Hepatic Encephalopathy. Clinical Gastroenterology and Hepatology, 19(11), 2456–2457. https://doi.org/10.1016/j.cgh.2021.01.046

Tavabie, O. D., Karvellas, C. J., Salehi, S., Speiser, J. L., Rose, C. F., Menon, K., Prachalias, A., Heneghan, M. A., Agarwal, K., Lee, W. M., McPhail, M. J. W., Aluvihare, V. R., Lee, W. M., Larson, A. M., Liou, I., Fix, O., Schilsky, M., McCashland, T., Hay, J. E., … Gottfried, M. (2021). A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure. Journal of Hepatology, 75(2), 424–434. https://doi.org/10.1016/j.jhep.2021.03.013

Bémeur, C., & Rose, C. F. (2020). Hepatic Encephalopathy, Sarcopenia, and Frailty. In P. Tandon & A. J. Montano-Loza (Eds.), Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future (pp. 247–263). Springer International Publishing. https://doi.org/10.1007/978-3-030-26226-6_17

Khazoom, F., L’Écuyer, S., Gilbert, K., Gagné, M.-A., Bouchard, C., Rose, C. F., Rousseau, G., & Charbonney, E. (2020). Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats. Journal of Trauma and Acute Care Surgery, 89(6), 1076–1084. https://doi.org/10.1097/TA.0000000000002868

Rose, C. F., Amodio, P., Bajaj, J. S., Dhiman, R. K., Montagnese, S., Taylor-Robinson, S. D., Vilstrup, H., & Jalan, R. (2020). Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy. Journal of Hepatology, 73(6), 1526–1547. https://doi.org/10.1016/j.jhep.2020.07.013

Rose, C. F., Clément, M.-A., Bosoi, C. R., Oliveira, M. M., Tremblay, M., & Bémeur, C. (2020). Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate (United States Patent No. US20200206174A1). https://patents.google.com/patent/US20200206174A1/en?inventor=Christopher+F.+Rose

Weiss, N., & Rose, C. F. (2020). Plasmatic osmolality and hepatic encephalopathy: A new player on the field? Liver International, 40(8), 1826–1828. https://doi.org/10.1111/liv.14549

Aamann, L., Ochoa‐Sanchez, R., Oliveira, M., Tremblay, M., Bémeur, C., Dam, G., Vilstrup, H., Aagaard, N. K., & Rose, C. F. (2019). Progressive resistance training prevents loss of muscle mass and strength in bile duct-ligated rats. Liver International, 39(4), 676–683. https://doi.org/10.1111/liv.13997

Matoori, S., Bao, Y., Schmidt, A., Fischer, E. J., Ochoa‐Sanchez, R., Tremblay, M., Oliveira, M. M., Rose, C. F., & Leroux, J. (2019). An Investigation of PS‐ b ‐PEO Polymersomes for the Oral Treatment and Diagnosis of Hyperammonemia. Small, 15(50), 1902347. https://doi.org/10.1002/smll.201902347

Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S. M., Varin, T. V., Gélinas, Y., Lamothe, J., Trottier, J., Mitchell, P. L., Guénard, F., Festuccia, W. T., Joubert, P., Rose, C. F., … Laplante, M. (2019). The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis. Molecular Metabolism, 30, 184–191. https://doi.org/10.1016/j.molmet.2019.09.014

Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S. M., Varin, T. V., Gélinas, Y., Lamothe, J., Trottier, J., Mitchell, P. L., Guénard, F., Festuccia, W. T., Joubert, P., Rose, C. F., … Laplante, M. (2019). The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. JCI Insight, 4(15). https://doi.org/10.1172/jci.insight.129492

Bhanji, R. A., Moctezuma-Velazquez, C., Duarte-Rojo, A., Ebadi, M., Ghosh, S., Rose, C., & Montano-Loza, A. J. (2018). Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis. Hepatology International, 12(4), 377–386. https://doi.org/10.1007/s12072-018-9875-9

Bissonnette, J., & Rose, C. F. (2018). Hepatic Encephalopathy: Pathophysiology—Brain. In Diagnosis and Management of Hepatic Encephalopathy (pp. 15–29). Springer, Cham. https://doi.org/10.1007/978-3-319-76798-7_2

Fortea, J. I., Zipprich, A., Fernandez-Mena, C., Puerto, M., Bosoi, C. R., Almagro, J., Hollenbach, M., Bañares, J., Rodríguez-Sánchez, B., Cercenado, E., Clément, M.-A., Rose, C. F., Bañares, R., Vaquero, J., & Ripoll, C. (2018). Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis. Liver International: Official Journal of the International Association for the Study of the Liver, 38(1), 102–112. https://doi.org/10.1111/liv.13510

Ochoa-Sanchez, R., & Rose, C. F. (2018). Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease. Journal of Clinical and Experimental Hepatology, 8(3), 262–271. https://doi.org/10.1016/j.jceh.2018.08.001

Reuter, B., Walter, K., Bissonnette, J., Leise, M. D., Lai, J., Tandon, P., Kamath, P. S., Biggins, S. W., Rose, C. F., Wade, J. B., & Bajaj, J. S. (2018). Assessment of the spectrum of hepatic encephalopathy: A multicenter study. Liver Transplantation, 24(5), 587–594. https://doi.org/10.1002/lt.25032

Weiss, N., Dam, G., & Rose, C. F. (2018). Ammonia: This is not the end but rather the end of the beginning. Journal of Hepatology, 68(6), 1110–1113. https://doi.org/10.1016/j.jhep.2018.03.027

Bosoi, C. R., Oliveira, M. M., Ochoa-Sanchez, R., Tremblay, M., Ten Have, G. A., Deutz, N. E., Rose, C. F., & Bemeur, C. (2017). The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis. Metabolic Brain Disease, 32(2), 513–518. https://doi.org/10.1007/s11011-016-9937-4

Dasarathy, S., Mookerjee, R. P., Rackayova, V., Rangroo Thrane, V., Vairappan, B., Ott, P., & Rose, C. F. (2017). Ammonia toxicity: from head to toe? Metabolic Brain Disease, 32(2), 529–538. https://doi.org/10.1007/s11011-016-9938-3

Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., & Rose, C. F. (2017). The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case–control study. Annals of Intensive Care, 7, 99. https://doi.org/10.1186/s13613-017-0323-0

Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., Rose, C. F., & for the US Acute Liver Failure Study Group. (2017). Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure. Hepatology, 65(3), 938–949. https://doi.org/10.1002/hep.28945

Karvellas, C. J., Speiser, J. L., Tremblay, M., Lee, W. M., Rose, C. F., & For the US Acute Liver Failure Study Group. (2017). In reply: Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure. Hepatology, 66(2), 670–671. https://doi.org/10.1002/hep.29194

Rose, C. F. (2017). What’s new in our understanding of the pathogenesis of hepatic encephalopathy? Clinical Liver Disease, 10(2), 29–31. https://doi.org/10.1002/cld.648

Agostoni, V., Lee, S. H., Forster, V., Kabbaj, M., Bosoi, C. R., Tremblay, M., Zadory, M., Rose, C. F., & Leroux, J.-C. (2016). Hyperammonemia: Liposome-Supported Peritoneal Dialysis for the Treatment of Hyperammonemia-Associated Encephalopathy (Adv. Funct. Mater. 46/2016). Advanced Functional Materials, 26(46), 8357–8357. https://doi.org/10.1002/adfm.201670300

Agostoni, V., Lee, S. H., Forster, V., Kabbaj, M., Bosoi, C. R., Tremblay, M., Zadory, M., Rose, C. F., & Leroux, J.-C. (2016). Liposome-Supported Peritoneal Dialysis for the Treatment of Hyperammonemia-Associated Encephalopathy. Advanced Functional Materials, 26(46), 8382–8389. https://doi.org/10.1002/adfm.201603519

Bémeur, C., Cudalbu, C., Dam, G., Thrane, A. S., Cooper, A. J. L., & Rose, C. F. (2016). Brain edema: a valid endpoint for measuring hepatic encephalopathy? Metabolic Brain Disease, 31(6), 1249–1258. https://doi.org/10.1007/s11011-016-9843-9

Kristiansen, R. G., Rose, C. F., & Ytrebø, L. M. (2016). Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy. Metabolic Brain Disease, 31(6), 1269–1273. https://doi.org/10.1007/s11011-016-9858-2

Nedredal, G. I., Elvevold, K., Chedid, M. F., Ytrebø, L. M., Rose, C. F., Sen, S., Smedsrød, B., Jalan, R., & Revhaug, A. (2016). Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure. Annals of Hepatology, 15(3), 427–435. https://doi.org/10.5604/16652681.1198821

Noiret, L., & Rose, C. F. (2016). Mathematical models and hepatology; oil and vinegar? Journal of Hepatology, 64(4), 768–769. https://doi.org/10.1016/j.jhep.2016.01.021

Rombouts, K., Bémeur, C., & Rose, C. F. (2016). Targeting the muscle for the treatment and prevention of hepatic encephalopathy. Journal of Hepatology, 65(5), 876–878. https://doi.org/10.1016/j.jhep.2016.08.014

Glorioso, J. M., Mao, S. A., Rodysill, B., Mounajjed, T., Kremers, W. K., Elgilani, F., Hickey, R. D., Haugaa, H., Rose, C. F., Amiot, B., & Nyberg, S. L. (2015). Pivotal preclinical trial of the spheroid reservoir bioartificial liver. Journal of Hepatology, 63(2), 388–398. https://doi.org/10.1016/j.jhep.2015.03.021

Glorioso, J. M., Mao, S. A., Rodysill, B., Mounajjed, T., Kremers, W. K., Elgilani, F., Hickey, R. D., Haugaa, H., Rose, C. F., Amiot, B., & Nyberg, S. L. (2015). Reply to: “Pivotal preclinical trial of the spheroid reservoir bioartificial liver.” Journal of Hepatology, 63(4), 1052–1053. https://doi.org/10.1016/j.jhep.2015.06.024

Bosoi, C. R., & Rose, C. F. (2014). Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease, 29(4), 919–925. https://doi.org/10.1007/s11011-014-9573-9

Bosoi, C. R., Tremblay, M., & Rose, C. F. (2014). Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats. Liver International, 34(9), 1322–1329. https://doi.org/10.1111/liv.12414

Bosoi, C. R., Zwingmann, C., Marin, H., Parent-Robitaille, C., Huynh, J., Tremblay, M., & Rose, C. F. (2014). Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. Journal of Hepatology, 60(3), 554–560. https://doi.org/10.1016/j.jhep.2013.10.011

Hadjihambi, A., Rose, C. F., & Jalan, R. (2014). Novel insights into ammonia-mediated neurotoxicity pointing to potential new therapeutic strategies. Hepatology, 60(3), 1101–1103. https://doi.org/10.1002/hep.27282

Kristiansen, R. G., Rose, C. F., Fuskevåg, O.-M., Mæhre, H., Revhaug, A., Jalan, R., & Ytrebø, L. M. (2014). L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G1024-1031. https://doi.org/10.1152/ajpgi.00244.2014

Rose, C. F. (2014). Ammonia: more than a neurotoxin? Liver International, 34(5), 649–651. https://doi.org/10.1111/liv.12518

Bosoi, C. R., & Rose, C. F. (2013). Brain edema in acute liver failure and chronic liver disease: Similarities and differences. Neurochemistry International, 62(4), 446–457. https://doi.org/10.1016/j.neuint.2013.01.015

Bosoi, C. R., & Rose, C. F. (2013). Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease, 28(2), 175–178. https://doi.org/10.1007/s11011-012-9351-5

Rose, C. F., Verkhratsky, A., & Parpura, V. (2013). Astrocyte glutamine synthetase: pivotal in health and disease. Biochemical Society Transactions, 41(6), 1518–1524. https://doi.org/10.1042/BST20130237

Ytrebø, L. M., & Rose, C. F. (2013). Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. Liver International, 33(4), 499–500. https://doi.org/10.1111/liv.12146

Bosoi, C. R., Yang, X., Huynh, J., Parent-Robitaille, C., Jiang, W., Tremblay, M., & Rose, C. F. (2012). Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure. Free Radical Biology and Medicine, 52(7), 1228–1235. https://doi.org/10.1016/j.freeradbiomed.2012.01.006

Rose, C. F. (2012). Ammonia-lowering strategies for the treatment of hepatic encephalopathy. Clinical Pharmacology & Therapeutics, 92(3), 321–331. https://doi.org/10.1038/clpt.2012.112

Sharma, V., Have, G. A. M. T., Ytrebo, L., Sen, S., Rose, C. F., Dalton, R. N., Turner, C., Revhaug, A., van-Eijk, H. M. H., Deutz, N. E. P., Jalan, R., Mookerjee, R. P., & Davies, N. A. (2012). Nitric oxide and l-arginine metabolism in a devascularized porcine model of acute liver failure. American Journal of Physiology - Gastrointestinal and Liver Physiology, 303(3), G435–G441. https://doi.org/10.1152/ajpgi.00268.2011

Bosoi, C. R., Parent-Robitaille, C., Anderson, K., Tremblay, M., & Rose, C. F. (2011). AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile-duct ligated rats. Hepatology, 53(6), 1995–2002. https://doi.org/10.1002/hep.24273

Kristiansen, R. G., Lindal, S., Myreng, K., Revhaug, A., Ytrebø, L. M., & Rose, C. F. (2010). Neuropathological changes in the brain of pigs with acute liver failure. Scandinavian Journal of Gastroenterology, 45(7–8), 935–943. https://doi.org/10.3109/00365521003675047

Rose, C. F. (2010). Increase brain lactate in hepatic encephalopathy: Cause or consequence? Neurochemistry International, 57(4), 389–394. https://doi.org/10.1016/j.neuint.2010.06.012

Yang, X., Bosoi, C. R., Jiang, W., Tremblay, M., & Rose, C. F. (2010). Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress. Metabolic Brain Disease, 25(1), 11–15. https://doi.org/10.1007/s11011-010-9174-1

Bosoi, C. R., & Rose, C. F. (2009). Identifying the direct effects of ammonia on the brain. Metabolic Brain Disease, 24(1), 95–102. https://doi.org/10.1007/s11011-008-9112-7

Ytrebø, L. M., Kristiansen, R. G., Maehre, H., Fuskevåg, O. M., Kalstad, T., Revhaug, A., Cobos, M. J., Jalan, R., & Rose, C. F. (2009). L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure. Hepatology, 50(1), 165–174. https://doi.org/10.1002/hep.22917

Rose, C., Davies, N. A., Ytrebø, L. M., Sen, S., Nedredal, G. I., Belanger, M., Revhaug, A., & Jalan, R. (2007). Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure. Hepatology, 46(6), 1883–1892. https://doi.org/10.1002/hep.21877

Chatauret, N., Desjardins, P., Zwingmann, C., Rose, C., Rao, K. V. R., & Butterworth, R. F. (2006). Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. Journal of Hepatology, 44(6), 1083–1088. https://doi.org/10.1016/j.jhep.2005.11.048

Rose, C. (2006). Effect of ammonia on astrocytic glutamate uptake/release mechanisms. Journal of Neurochemistry, 97 Suppl 1, 11–15. https://doi.org/10.1111/j.1471-4159.2006.03796.x

Rose, C., & Jalan, R. (2006). Congenital glutamine deficiency with glutamine synthetase mutations. New England Journal of Medicine, 354(10), 1093–1094; author reply 1093-4. https://doi.org/10.1056/NEJMc053332

Sen, S., Rose, C., Ytrebø, L. M., Davies, N. A., Nedredal, G. I., Drevland, S. S., Kjønnø, M., Prinzen, F. W., Hodges, S. J., Deutz, N. E. P., Williams, R., Butterworth, R. F., Revhaug, A., & Jalan, R. (2006). Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Critical Care Medicine, 34(1), 158–164. https://doi.org/10.1097/01.CCM.0000196203.39832.3C

Ytrebø, L. M., Sen, S., Rose, C., Davies, N. A., Nedredal, G. I., Fuskevaag, O.-M., Have, G. A. M. T., Prinzen, F. W., Williams, R., Deutz, N. E. P., Jalan, R., & Revhaug, A. (2006). Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis. Scandinavian Journal of Gastroenterology, 41(11), 1350–1360. https://doi.org/10.1080/00365520600714527

Ytrebø, L. M., Sen, S., Rose, C., Have, G. A. M. T., Davies, N. A., Hodges, S., Nedredal, G. I., Romero-Gomez, M., Williams, R., Revhaug, A., Jalan, R., & Deutz, N. E. P. (2006). Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291(3), G373–G381. https://doi.org/10.1152/ajpgi.00440.2005

Bélanger, M., Desjardins, P., Chatauret, N., Rose, C., & Butterworth, R. F. (2005). Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. Journal of Hepatology, 42(5), 694–699. https://doi.org/10.1016/j.jhep.2004.12.029

Rose, C., & Felipo, V. (2005). Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metabolic Brain Disease, 20(4), 275–283. https://doi.org/10.1007/s11011-005-7906-4

Rose, C., Kresse, W., & Kettenmann, H. (2005). Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH. The Journal of Biological Chemistry, 280(22), 20937–20944. https://doi.org/10.1074/jbc.M412448200

Vaquero, J., Rose, C., & Butterworth, R. F. (2005). Keeping cool in acute liver failure: rationale for the use of mild hypothermia. Journal of Hepatology, 43(6), 1067–1077. https://doi.org/10.1016/j.jhep.2005.05.039

Jalan, R., & Rose, C. (2004). Hypothermia in acute liver failure. Metabolic Brain Disease, 19(3–4), 215–221. https://doi.org/10.1023/B:MEBR.0000043971.72170.a2

Rose, C., & Jalan, R. (2004). Is minimal hepatic encephalopathy completely reversible following liver transplantation? Liver Transplantation, 10(1), 84–87. https://doi.org/10.1002/lt.20030

Sen, S., Ytrebø, L. M., Rose, C., Fuskevaag, O.-M., Davies, N. A., Nedredal, G. I., Williams, R., Revhaug, A., & Jalan, R. (2004). Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs. Intensive Care Med, 30(3), 496–501. https://doi.org/10.1007/s00134-003-2141-0

Ytrebø, L. M., Ekse, S., Sen, S., Rose, C., Nedredal, G. I., Fuskevåg, O.-M., Jalan, R., & Revhaug, A. (2004). Contractile response of femoral arteries in pigs with acute liver failure. Scandinavian Journal of Gastroenterology, 39(10), 1000–1004. https://doi.org/10.1080/00365520410003254

Zwingmann, C., Chatauret, N., Rose, C., Leibfritz, D., & Butterworth, R. F. (2004). Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain Research, 999(1), 118–123. https://doi.org/10.1016/j.brainres.2003.11.048

Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D., & Butterworth, R. F. (2003). Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology, 125(3), 815–824. https://doi.org/10.1016/S0016-5085(03)01054-0

Desjardins, P., Sauvageau, A., Bouthillier, A., Navarro, D., Hazell, A. S., Rose, C., & Butterworth, R. F. (2003). Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. Neurochemistry International, 42(4), 299–303. https://doi.org/10.1016/S0197-0186(02)00101-8

Chatauret, N., Rose, C., & Butterworth, R. F. (2002). Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. Metabolic Brain Disease, 17(4), 445–451. https://doi.org/10.1023/A:1021982523691

Rose, C. (2002). Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release? Metabolic Brain Disease, 17(4), 251–261. https://doi.org/10.1023/A:1021945515514

Sauvageau, A., Desjardins, P., Lozeva, V., Rose, C., Hazell, A. S., Bouthillier, A., & Butterworth, R. F. (2002). Increased expression of “peripheral-type” benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis. Metabolic Brain Disease, 17(1), 3–11. https://doi.org/10.1023/A:1014044128845

Chatauret, N., Rose, C., Therrien, G., & Butterworth, R. F. (2001). Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure. Metabolic Brain Disease, 16(1–2), 95–102. https://doi.org/10.1023/A:1011622830569

Michalak, A., Rose, C., & Butterworth, R. F. (2001). Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure. Neurochem Int, 38(1), 25–30. https://doi.org/10.1016/S0197-0186(00)00048-6

Rose, C., Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A., & Butterworth, R. F. (2000). Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology, 31(4), 872–877. https://doi.org/10.1053/he.2000.5923

Desjardins, P., Rao, K. V., Michalak, A., Rose, C., & Butterworth, R. F. (1999). Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metabolic Brain Disease, 14(4), 273–280. https://doi.org/10.1023/A:1020741226752

Rose, C., Butterworth, R. F., Zayed, J., Normandin, L., Todd, K., Michalak, A., Spahr, L., Huet, P. M., & Pomier-Layrargues, G. (1999). Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology, 117(3), 640–644. https://doi.org/10.1016/S0016-5085(99)70457-9

Rose, C., Michalak, A., Rao, K. V., Quack, G., Kircheis, G., & Butterworth, R. F. (1999). L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology, 30(3), 636–640. https://doi.org/10.1002/hep.510300311

Layrargues, G. P., Rose, C., Spahr, L., Zayed, J., Normandin, L., & Butterworth, R. F. (1998). Role of manganese in the pathogenesis of portal-systemic encephalopathy. Metabolic Brain Disease, 13(4), 311–317. https://doi.org/10.1023/A:1020636809063

Michalak, A., Rose, C., Buu, P. N., & Butterworth, R. F. (1998). Evidence for altered central noradrenergic function in experimental acute liver failure in the rat. Hepatology, 27(2), 362–368. https://doi.org/10.1002/hep.510270208

Rose, C., Michalak, A., Pannunzio, P., Therrien, G., Quack, G., Kircheis, G., & Butterworth, R. F. (1998). L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metabolic Brain Disease, 13(2), 147–157. https://doi.org/10.1023/A:1020613314572

Knecht, K., Michalak, A., Rose, C., Rothstein, J. D., & Butterworth, R. F. (1997). Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neuroscience Letters, 229(3), 201–203. https://doi.org/10.1016/S0304-3940(97)00444-8

Therrien, G., Rose, C., Butterworth, J., & Butterworth, R. F. (1997). Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology, 25(3), 551–556. https://doi.org/10.1002/hep.510250310

Waele, J. P. de, Audet, R. M., Rose, C., & Butterworth, R. F. (1997). The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference? Alcohol Clin Exp Res, 21(2), 305–310. https://doi.org/10.1111/j.1530-0277.1997.tb03765.x

Michalak, A., Rose, C., Butterworth, J., & Butterworth, R. F. (1996). Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology (Baltimore, Md.), 24(4), 908–913. https://doi.org/10.1002/hep.510240425