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Alcohol is broken down in the body to a compound called acetaldehyde. This is then normally broken down further by an enzyme in the liver called aldehyde dehydrogenase. Antabuse stops this enzyme from working. This means that when alcohol is consumed, the body cannot process it normally. Instead, acetaldehyde accumulates in the bloodstream, causing a variety of unpleasant effects (e.g., flushing, dizziness, headache, nausea and vomiting) even when a small amount of alcohol is consumed. This reaction to alcohol, known as the disulfiram reaction is usually enough to deter people from having another drink.


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