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Generic Antabuse acts by blocking the breakdown of alcohol, causing unpleasant side effects (eg, vomiting, upset stomach) when even a small amount of alcohol is consumed. It is an alcohol-abuse deterrent.


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Consuming ethanol (alcohol) while taking metronidazole has long been thought to have a disulfiram-like reaction with effects that can include nausea, vomiting, flushing of the skin, tachycardia (accelerated heart rate), and shortness of breath. typically a 2006 medicines handbook warns that consumption of alcohol should be avoided by patients during systemic metronidazole therapy and for at least 48 hours after completion of treatment.however there are studies calling into question the interaction of alcohol and metronidazole,[19] and the mechanism of this reaction in the clinical setting has been questioned by some authors, and a possible central toxic serotonin reaction for the alcohol intolerance suggested.
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