Nedredal, G. I., Elvevold, K., Chedid, M. F., Ytrebø, L. M., Rose, C. F., Sen, S., … Revhaug, A. (2016). Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure. Annals of Hepatology, 15(3), 427–435. https://doi.org/10.5604/16652681.1198821

Bémeur, C., Cudalbu, C., Dam, G., Thrane, A. S., Cooper, A. J. L., & Rose, C. F. (2016). Brain edema: a valid endpoint for measuring hepatic encephalopathy? Metabolic Brain Disease. https://doi.org/10.1007/s11011-016-9843-9

Kristiansen, R. G., Rose, C. F., & Ytrebø, L. M. (2016). Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy. Metabolic Brain Disease. https://doi.org/10.1007/s11011-016-9858-2

Noiret, L., & Rose, C. F. (2016). Mathematical models and hepatology; oil and vinegar? Journal of Hepatology, 64(4), 768–769. https://doi.org/10.1016/j.jhep.2016.01.021

Glorioso, J. M., Mao, S. A., Rodysill, B., Mounajjed, T., Kremers, W. K., Elgilani, F., … Nyberg, S. L. (2015). Pivotal preclinical trial of the spheroid reservoir bioartificial liver. Journal of Hepatology, 63(2), 388–398. https://doi.org/10.1016/j.jhep.2015.03.021

Rose, C. F. (2014). Ammonia: more than a neurotoxin? Liver International, 34(5), 649–651. https://doi.org/10.1111/liv.12518

Bosoi, C. R., & Rose, C. F. (2014). Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease, 29(4), 919–925. https://doi.org/10.1007/s11011-014-9573-9

Bosoi, C. R., Zwingmann, C., Marin, H., Parent-Robitaille, C., Huynh, J., Tremblay, M., & Rose, C. F. (2014). Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. Journal of Hepatology, 60(3), 554–560. https://doi.org/10.1016/j.jhep.2013.10.011

Bosoi, C. R., Tremblay, M., & Rose, C. F. (2014). Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats. Liver International, 34(9), 1322–1329. https://doi.org/10.1111/liv.12414

Kristiansen, R. G., Rose, C. F., Fuskevåg, O.-M., Mæhre, H., Revhaug, A., Jalan, R., & Ytrebø, L. M. (2014). L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G1024–1031. https://doi.org/10.1152/ajpgi.00244.2014

Hadjihambi, A., Rose, C. F., & Jalan, R. (2014). Novel insights into ammonia-mediated neurotoxicity pointing to potential new therapeutic strategies. Hepatology, 60(3), 1101–1103. https://doi.org/10.1002/hep.27282

Rose, C. F., Verkhratsky, A., & Parpura, V. (2013). Astrocyte glutamine synthetase: pivotal in health and disease. Biochemical Society Transactions, 41(6), 1518–1524. https://doi.org/10.1042/BST20130237

Bosoi, C. R., & Rose, C. F. (2013a). Brain edema in acute liver failure and chronic liver disease: Similarities and differences. Neurochemistry International, 62(4), 446–457. https://doi.org/10.1016/j.neuint.2013.01.015

Bosoi, C. R., & Rose, C. F. (2013b). Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy. Metabolic Brain Disease, 28(2), 175–178. https://doi.org/10.1007/s11011-012-9351-5

Ytrebø, L. M., & Rose, C. F. (2013). Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. Liver International, 33(4), 499–500. https://doi.org/10.1111/liv.12146

Rose, C. F. (2012). Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy. Clinical Pharmacology & Therapeutics, 92(3), 321–331. https://doi.org/10.1038/clpt.2012.112

Sharma, V., Have, G. A. M. T., Ytrebo, L., Sen, S., Rose, C. F., Dalton, R. N., … Davies, N. A. (2012). Nitric oxide and l-arginine metabolism in a devascularized porcine model of acute liver failure. American Journal of Physiology - Gastrointestinal and Liver Physiology, 303(3), G435–G441. https://doi.org/10.1152/ajpgi.00268.2011

Bosoi, C. R., Yang, X., Huynh, J., Parent-Robitaille, C., Jiang, W., Tremblay, M., & Rose, C. F. (2012). Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure. Free Radical Biology and Medicine, 52(7), 1228–1235. https://doi.org/10.1016/j.freeradbiomed.2012.01.006

Bosoi, C. R., Parent-Robitaille, C., Anderson, K., Tremblay, M., & Rose, C. F. (2011). AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile-duct ligated rats. Hepatology, 53(6), 1995–2002. https://doi.org/10.1002/hep.24273

Rose, C. F. (2010). Increase brain lactate in hepatic encephalopathy: Cause or consequence? Neurochemistry International, 57(4), 389–394. https://doi.org/10.1016/j.neuint.2010.06.012

Kristiansen, R. G., Lindal, S., Myreng, K., Revhaug, A., Ytrebø, L. M., & Rose, C. F. (2010). Neuropathological changes in the brain of pigs with acute liver failure. Scandinavian Journal of Gastroenterology, 45(7-8), 935–943. https://doi.org/10.3109/00365521003675047

Yang, X., Bosoi, C. R., Jiang, W., Tremblay, M., & Rose, C. F. (2010). Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress. Metabolic Brain Disease, 25(1), 11–15. https://doi.org/10.1007/s11011-010-9174-1

Bosoi, C. R., & Rose, C. F. (2009). Identifying the direct effects of ammonia on the brain. Metabolic Brain Disease, 24(1), 95–102. https://doi.org/10.1007/s11011-008-9112-7

Ytrebø, L. M., Kristiansen, R. G., Maehre, H., Fuskevåg, O. M., Kalstad, T., Revhaug, A., … Rose, C. F. (2009). L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure. Hepatology, 50(1), 165–174. https://doi.org/10.1002/hep.22917

Rose, C., Davies, N. A., Ytrebø, L. M., Sen, S., Nedredal, G. I., Belanger, M., … Jalan, R. (2007). Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure. Hepatology, 46(6), 1883–92. https://doi.org/10.1002/hep.21877

Rose, C., & Jalan, R. (2006). Congenital glutamine deficiency with glutamine synthetase mutations. New England Journal of Medicine, 354(10), 1093–4; author reply 1093–4. https://doi.org/10.1056/NEJMc053332

Chatauret, N., Desjardins, P., Zwingmann, C., Rose, C., Rao, K. V. R., & Butterworth, R. F. (2006). Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. Journal of Hepatology, 44(6), 1083–1088. https://doi.org/10.1016/j.jhep.2005.11.048

Sen, S., Rose, C., Ytrebø, L. M., Davies, N. A., Nedredal, G. I., Drevland, S. S., … Jalan, R. (2006). Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study. Critical Care Medicine, 34(1), 158–164. https://doi.org/10.1097/01.CCM.0000196203.39832.3C

Rose, C. (2006). Effect of ammonia on astrocytic glutamate uptake/release mechanisms. Journal of Neurochemistry, 97 Suppl 1, 11–15. https://doi.org/10.1111/j.1471-4159.2006.03796.x

Ytrebø, L. M., Sen, S., Rose, C., Have, G. A. M. T., Davies, N. A., Hodges, S., … Deutz, N. E. P. (2006). Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291(3), G373–G381. https://doi.org/10.1152/ajpgi.00440.2005

Ytrebø, L. M., Sen, S., Rose, C., Davies, N. A., Nedredal, G. I., Fuskevaag, O.-M., … Revhaug, A. (2006). Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis. Scandinavian Journal of Gastroenterology, 41(11), 1350–1360. https://doi.org/10.1080/00365520600714527

Rose, C., Kresse, W., & Kettenmann, H. (2005). Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH. The Journal of Biological Chemistry, 280(22), 20937–20944. https://doi.org/10.1074/jbc.M412448200

Vaquero, J., Rose, C., & Butterworth, R. F. (2005). Keeping cool in acute liver failure: rationale for the use of mild hypothermia. Journal of Hepatology, 43(6), 1067–1077. https://doi.org/10.1016/j.jhep.2005.05.039

Rose, C., & Felipo, V. (2005). Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metabolic Brain Disease, 20(4), 275–83. https://doi.org/10.1007/s11011-005-7906-4

Bélanger, M., Desjardins, P., Chatauret, N., Rose, C., & Butterworth, R. F. (2005). Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. Journal of Hepatology, 42(5), 694–699. https://doi.org/10.1016/j.jhep.2004.12.029

Sen, S., Ytrebø, L. M., Rose, C., Fuskevaag, O.-M., Davies, N. A., Nedredal, G. I., … Jalan, R. (2004). Albumin dialysis: a new therapeutic strategy for intoxication from protein-bound drugs. Intensive Care Medicine, 30(3), 496–501. https://doi.org/10.1007/s00134-003-2141-0

Ytrebø, L. M., Ekse, S., Sen, S., Rose, C., Nedredal, G. I., Fuskevåg, O.-M., … Revhaug, A. (2004). Contractile response of femoral arteries in pigs with acute liver failure. Scandinavian Journal of Gastroenterology, 39(10), 1000–1004. https://doi.org/10.1080/00365520410003254

Jalan, R., & Rose, C. (2004). Hypothermia in acute liver failure. Metabolic Brain Disease, 19(3-4), 215–221. https://doi.org/10.1023/B:MEBR.0000043971.72170.a2

Rose, C., & Jalan, R. (2004). Is minimal hepatic encephalopathy completely reversible following liver transplantation? Liver Transplantation, 10(1), 84–87. https://doi.org/10.1002/lt.20030

Zwingmann, C., Chatauret, N., Rose, C., Leibfritz, D., & Butterworth, R. F. (2004). Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia. Brain Research, 999(1), 118–123. https://doi.org/10.1016/j.brainres.2003.11.048

Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D., & Butterworth, R. F. (2003). Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Gastroenterology, 125(3), 815–824. https://doi.org/10.1016/S0016-5085(03)01054-0

Desjardins, P., Sauvageau, A., Bouthillier, A., Navarro, D., Hazell, A. S., Rose, C., & Butterworth, R. F. (2003). Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. Neurochemistry International, 42(4), 299–303. https://doi.org/10.1016/S0197-0186(02)00101-8

Sauvageau, A., Desjardins, P., Lozeva, V., Rose, C., Hazell, A. S., Bouthillier, A., & Butterworth, R. F. (2002). Increased expression of “peripheral-type” benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis. Metabolic Brain Disease, 17(1), 3–11. https://doi.org/10.1023/A:1014044128845

Rose, C. (2002). Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release? Metabolic Brain Disease, 17(4), 251–261. https://doi.org/10.1023/A:1021945515514

Chatauret, N., Rose, C., & Butterworth, R. F. (2002). Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. Metabolic Brain Disease, 17(4), 445–451. https://doi.org/10.1023/A:1021982523691

Michalak, A., Rose, C., & Butterworth, R. F. (2001). Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure. Neurochemistry International, 38(1), 25–30. https://doi.org/10.1016/S0197-0186(00)00048-6

Chatauret, N., Rose, C., Therrien, G., & Butterworth, R. F. (2001). Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure. Metabolic Brain Disease, 16(1-2), 95–102. https://doi.org/10.1023/A:1011622830569

Rose, C., Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A., & Butterworth, R. F. (2000). Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology, 31(4), 872–877. https://doi.org/10.1053/he.2000.5923

Desjardins, P., Rao, K. V., Michalak, A., Rose, C., & Butterworth, R. F. (1999). Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metabolic Brain Disease, 14(4), 273–280. https://doi.org/10.1023/A:1020741226752

Rose, C., Michalak, A., Rao, K. V., Quack, G., Kircheis, G., & Butterworth, R. F. (1999). L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology, 30(3), 636–640. https://doi.org/10.1002/hep.510300311

Rose, C., Butterworth, R. F., Zayed, J., Normandin, L., Todd, K., Michalak, A., … Pomier-Layrargues, G. (1999). Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology, 117(3), 640–644. https://doi.org/10.1016/S0016-5085(99)70457-9

Michalak, A., Rose, C., Buu, P. N., & Butterworth, R. F. (1998). Evidence for altered central noradrenergic function in experimental acute liver failure in the rat. Hepatology (Baltimore, Md.), 27(2), 362–368. https://doi.org/10.1002/hep.510270208

Rose, C., Michalak, A., Pannunzio, P., Therrien, G., Quack, G., Kircheis, G., & Butterworth, R. F. (1998). L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metabolic Brain Disease, 13(2), 147–157. https://doi.org/10.1023/A:1020613314572

Layrargues, G. P., Rose, C., Spahr, L., Zayed, J., Normandin, L., & Butterworth, R. F. (1998). Role of manganese in the pathogenesis of portal-systemic encephalopathy. Metabolic Brain Disease, 13(4), 311–317. https://doi.org/10.1023/A:1020636809063

Knecht, K., Michalak, A., Rose, C., Rothstein, J. D., & Butterworth, R. F. (1997). Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neuroscience Letters, 229(3), 201–203. https://doi.org/10.1016/S0304-3940(97)00444-8

Therrien, G., Rose, C., Butterworth, J., & Butterworth, R. F. (1997). Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat. Hepatology, 25(3), 551–556. https://doi.org/10.1002/hep.510250310

Waele, J. P. de, Audet, R. M., Rose, C., & Butterworth, R. F. (1997). The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference? Alcohol Clin Exp Res, 21(2), 305–310. https://doi.org/10.1111/j.1530-0277.1997.tb03765.x

Michalak, A., Rose, C., Butterworth, J., & Butterworth, R. F. (1996). Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology (Baltimore, Md.), 24(4), 908–913. https://doi.org/10.1002/hep.510240425