Multi-scale modelling in computational biomedicine

Item Type Journal Article
Author Peter M A Sloot
Author Alfons G Hoekstra
URL http://www.ncbi.nlm.nih.gov/pubmed/20028713
Publication Briefings in Bioinformatics
ISSN 1477-4054
Date Dec 22, 2009
Extra PMID: 20028713
Journal Abbr Brief Bioinform
DOI 10.1093/bib/bbp038
Accessed 2010-01-01 14:13:45
Library Catalog NCBI PubMed
Abstract The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.
Title Multi-scale modelling in computational biomedicine
Date Added 2009-01-01 09:13
Date Modified 2009-01-01 09:13